Lisa from Books Lists Life says, "The two I've already chosen are: gods in Alabama by Jackson and The Optimist's Daughter by Welty. I'm thinking about the first Miss Julia, but wouldn't mind something with a little bluesy heat to it."
Let's help her with some "Bluesy Heat" ideas!
I immediately thought of Robert Johnson, since I live near the "crossroads", and that lead to Walter Mosely's excellent RL's Dream. I'll accept Mr. Mosley as a Southern; although, he was born in California. The reason, I've heard him speak in interviews, and I'm certain his peoples were from the South. ;D
I also ran across this excellent article by a bookseller on the subject of "bluesy" books.
Other suggestions anyone?